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Risk factors for ventilator-associated pneumonia among patients undergoing major oncological surgery

Yutao Liu, Yaxia Di, Shuai Fu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 239-246 doi: 10.1007/s11684-017-0509-8

Abstract: We aimed to identify risk factors for ventilator-associated pneumonia (VAP) in patients undergoing SHNCThe rate of VAP, risk factors for VAP, and biological aspects of VAP were retrospectively evaluated.Tracheostomy was an independent protective factor for VAP.The median length of stay in the ICU for patients who did or did not develop VAP was 8.0 and 6.5 daysMortality among patients who did or did not develop VAP was 16.8% and 8.4%, respectively (P<

Keywords： ventilator-associated pneumonia (VAP)     pneumonia     risk factors     surgery for head and neck cancer (SHNC)    

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Clinical factors associated with composition of lung microbiota and important taxa predicting clinicalprognosis in patients with severe community-acquired pneumonia

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 389-402 doi: 10.1007/s11684-021-0856-3

Abstract: the key features and prognostic roles of lung microbiota in patients with severe community-acquired pneumoniaincrease in α-diversity and the abundance of the families Prevotellaceae and Actinomycetaceae were associatedThe positive bacteria lab test results, AKI, and plasma MIP-1β level were associated with patients’ lung

Keywords： severe community-acquired pneumonia     lung microbiota     clinical improvements     7-category ordinal scale    

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Analysis of antibiotic usage for viral community-acquired pneumonia in adults

Rongmeng Jiang, Bing Han, Chang Dou, Fei Zhou, Bin Cao, Xingwang Li

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 139-143 doi: 10.1007/s11684-019-0736-2

Abstract: The rationale for the antibiotic treatment of viral community-acquired pneumonia (CAP) in adults wasClinical data from 166 patients diagnosed with viral pneumonia across 14 hospitals in Beijing from NovemberA total of 163 (98.3%) patients with viral pneumonia were treated with antibiotics.

Keywords： adult     antibiotic     viral pneumonia    

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Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 378-388 doi: 10.1007/s11684-021-0840-y

Abstract: and corticosteroid resistance has been reported in patients with Mycoplasma pneumoniae (MP) pneumonia

Keywords： severe Mycoplasma pneumoniae pneumonia     children     proteomics     Fc fragment of the IgG-binding protein    

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Crk-associated substrate, vascular smooth muscle and hypertension

TANG Dale

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 323-331 doi: 10.1007/s11684-008-0062-6

Abstract: Crk-associated substrate (CAS), the first discovered member of the adapter protein CAS family, has been

Keywords： Contraction stimulation     phosphatase-proline     molecular structure     discovered     hypertension    

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Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 459-466 doi: 10.1007/s11684-021-0841-x

Abstract: Whether Fanconi anemia (FA) heterozygotes are predisposed to bone marrow failure and hematologic neoplasm is a crucial but unsettled issue in cancer prevention and family consulting. We retrospectively analyzed rare possibly significant variations (PSVs) in the five most obligated FA genes, BRCA2, FANCA, FANCC, FANCD2, and FANCG, in 788 patients with aplastic anemia (AA) and hematologic malignancy. Sixty-eight variants were identified in 66 patients (8.38%). FANCA was the most frequently mutated gene (n = 29), followed by BRCA2 (n = 20). Compared with that of the ExAC East Asian dataset, the overall frequency of rare PSVs was higher in our cohort (P = 0.016). BRCA2 PSVs showed higher frequency in acute lymphocytic leukemia (P = 0.038), and FANCA PSVs were significantly enriched in AA and AML subgroups (P = 0.020; P = 0.008). FA-PSV-positive MDS/AML patients had a higher tumor mutation burden, higher rate of cytogenetic abnormalities, less epigenetic regulation, and fewer spliceosome gene mutations than those of FA-PSV-negative MDS/AML patients (P = 0.024, P = 0.029, P = 0.024, and P = 0.013). The overall PSV enrichment in our cohort suggests that heterozygous mutations of FA genes contribute to hematopoietic failure and leukemogenesis.

Keywords： Fanconi anemia     aplastic anemia     hematologic malignancy     germline predisposition    

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New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 714-722 doi: 10.1007/s11684-021-0888-8

Abstract: A new definition of metabolic dysfunction-associated fatty liver disease (MAFLD) has recently been proposedParticipants without NAFLD but diagnosed according to MAFLD definition were associated with higher riskIn conclusion, MAFLD was associated with new-onset elevated baPWV and albuminuria independently of body

Keywords： metabolic dysfunction-associated fatty liver disease     non-alcoholic fatty liver disease     fibrosis score    

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Mouth the mirror of lungs: where does the connection lie?

Jananni Muthu,Sivaramakrishnan Muthanandam,Jaideep Mahendra

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 405-409 doi: 10.1007/s11684-016-0476-5

Abstract:

Periodontitis is the chronic destructive disease of the periodontium (Gums) caused by host bacterial interactions. The effect of such host bacterial interactions in oral cavity also evokes a systemic response. Numerous studies have found common mechanisms of destruction for periodontal diseases and other chronic diseases like diabetes mellitus, atherosclerosis, respiratory diseases, and adverse pregnancy outcomes. Oral colonization by respiratory pathogens appears to be a risk factor for development of respiratory diseases and oral interventions aimed at reducing oral bacterial count have resulted in reduced incidence of these reparatory illness. This reflects the importance of oral hygiene among patients with respiratory illness. This review highlights the association between periodontal diseases and respiratory diseases.

Keywords： periodontitis     respiratory diseases     acute pneumonia     COPD    

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Transparent exopolymer particles (TEPs)-associated protobiofilm: A neglected contributor to biofouling

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 4, doi: 10.1007/s11783-020-1361-7

Abstract:

• Bacteria could easily and quickly attached onto TEP to form protobiofilms.

Keywords： Transparent exopolymer particles (TEPs)     TEP-protobiofilm     Bacteria attachment     Biofouling of membrane    

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The effect of orbital radiation therapy on thyroid-associated orbitopathy complicated with dysthyroid

Yang Wang, Huifang Zhou, Xianqun Fan

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 359-364 doi: 10.1007/s11684-017-0528-5

Abstract:

Thyroid-associated orbitopathy (TAO) is an inflammatory autoimmune disorder.

Keywords： thyroid-associated orbitopathy     dysthyroid optic neuropathy     orbital radiation therapy    

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Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy

Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 667-677 doi: 10.1007/s11684-017-0583-y

Abstract: recent progresses in platelet membrane-based drug delivery and unique strategies that target tumor-associated

Keywords： platelet-mimicking delivery systems     tumor-associated platelets     cancer therapy     EPR effect    

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Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 33-42 doi: 10.1007/s11684-019-0735-3

Abstract: However, given the nature of the non-specific activation of effector T cells, ICIs are remarkably associated

Keywords： cancer     immunotherapy     immune checkpoint inhibitors     immune-related adverse events     review    

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Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

Aixiu Qiao,Feng Gu,Xiaojing Guo,Xinmin Zhang,Li Fu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 33-40 doi: 10.1007/s11684-016-0431-5

Abstract: Cancer-associated fibroblasts (CAFs), the most abundant cells in tumor stroma, secrete various active

Keywords： cancer-associated fibroblast     breast cancer     progression     prognosis    

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Investigation on sampling artifacts of particle associated PAHs using ozone denuder systems

Kai LIU, Fengkui DUAN, Kebin HE, Yongliang MA, Yuan CHENG

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 2,   Pages 284-292 doi: 10.1007/s11783-013-0555-7

Abstract: The goal of this work was to investigate particle associated PAHs sampling artifacts caused by ozoneHigh temperature can increase loss of particle associated PAHs during sampling.

Keywords： particle associated polycyclic aromatic hydrocarbons (PAHs)     ozone     denuder     sampling artifacts    

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Regulation of exogenous bFGF gene mediated by recombinant adeno-associated virus

Ke SONG, Nianjing RAO, Meiling CHEN, Yingguang CAO

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 158-163 doi: 10.1007/s11684-009-0042-5

Abstract: The regulatory effect of basic fibroblast growth factor (bFGF) mediated by recombinant adeno-associated

Keywords： tetracycline regulatory system     adeno-associated virus     basic fibroblast growth factor     gene regulation    

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Title Author Date Type Operation

Risk factors for ventilator-associated pneumonia among patients undergoing major oncological surgery

Yutao Liu, Yaxia Di, Shuai Fu

Journal Article

Clinical factors associated with composition of lung microbiota and important taxa predicting clinicalprognosis in patients with severe community-acquired pneumonia

Journal Article

Analysis of antibiotic usage for viral community-acquired pneumonia in adults

Rongmeng Jiang, Bing Han, Chang Dou, Fei Zhou, Bin Cao, Xingwang Li

Journal Article

Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein

Journal Article

Crk-associated substrate, vascular smooth muscle and hypertension

TANG Dale

Journal Article

Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies

Journal Article

New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse

Journal Article

Mouth the mirror of lungs: where does the connection lie?

Jananni Muthu,Sivaramakrishnan Muthanandam,Jaideep Mahendra

Journal Article

Transparent exopolymer particles (TEPs)-associated protobiofilm: A neglected contributor to biofouling

Journal Article

The effect of orbital radiation therapy on thyroid-associated orbitopathy complicated with dysthyroid

Yang Wang, Huifang Zhou, Xianqun Fan

Journal Article

Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy

Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie

Journal Article

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Journal Article

Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

Aixiu Qiao,Feng Gu,Xiaojing Guo,Xinmin Zhang,Li Fu

Journal Article

Investigation on sampling artifacts of particle associated PAHs using ozone denuder systems

Kai LIU, Fengkui DUAN, Kebin HE, Yongliang MA, Yuan CHENG

Journal Article

Regulation of exogenous bFGF gene mediated by recombinant adeno-associated virus

Ke SONG, Nianjing RAO, Meiling CHEN, Yingguang CAO

Journal Article